Effect of DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in hyperlipidemic animals
Hyperlipidemia is a major risk factor associated with increased risk of myocardial infarction. Dipeptidyl peptidase-4 (DPP-4) inhibitors such as sitagliptin are a class of oral anti-diabetic drugs with secondary pleiotropic effects on metabolic and cardiovascular parameters. This study aimed to dete...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
University of Szeged
Szeged
2018
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| Sorozat: | Acta biologica Szegediensis
62 No. 2 |
| Kulcsszavak: | Állattudomány |
| doi: | 10.14232/abs.2018.2.180-189 |
| Online Access: | http://acta.bibl.u-szeged.hu/58187 |
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| 024 | 7 | |a 10.14232/abs.2018.2.180-189 |2 doi | |
| 040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 2 | |a Al-awar Amin | |
| 245 | 1 | 0 | |a Effect of DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in hyperlipidemic animals |h [elektronikus dokumentum] / |c Al-awar Amin |
| 260 | |a University of Szeged |b Szeged |c 2018 | ||
| 300 | |a 180-189 | ||
| 490 | 0 | |a Acta biologica Szegediensis |v 62 No. 2 | |
| 520 | 3 | |a Hyperlipidemia is a major risk factor associated with increased risk of myocardial infarction. Dipeptidyl peptidase-4 (DPP-4) inhibitors such as sitagliptin are a class of oral anti-diabetic drugs with secondary pleiotropic effects on metabolic and cardiovascular parameters. This study aimed to determine the possible cardioprotective effects of sitagliptin on ischemia-reperfusion (I/R) injury in animals kept on high-fat diet. Male Wistar rats were fed with high-fat diet (HF) for 12 weeks, to induce hyperlipidemia. During the last two weeks of the feeding period, animals were orally treated with different doses of sitagliptin (Sitg: 25, 50, 100, and 150 mg/kg/day), or saline as a control. Heart tissues were then isolated and subjected to two different I/R-injury protocols for infarct size (IS) measurement and biochemical analysis. To test the role of NOS enzyme, NOS inhibitor (L-NAME) was injected intraperitoneally for IS evaluation. As an effective dose, Sitg (50 mg) exhibited a significant impact on IS. NOS activity increased significantly in the Sitg (50 mg) treated groups; however this protective effect was abolished in the presence of L-NAME. The protective effect of Sitg that was mediated by TRP channels in our previous study on normolipidemic animals was abrogated in animals fed with high-fat diet. | |
| 695 | |a Állattudomány | ||
| 700 | 0 | 1 | |a Almási Nikoletta |e aut |
| 700 | 0 | 1 | |a Szabó Renáta |e aut |
| 700 | 0 | 1 | |a Ménesi Rudolf |e aut |
| 700 | 0 | 1 | |a Szűcs Gergő |e aut |
| 700 | 0 | 1 | |a Török Szilvia |e aut |
| 700 | 0 | 1 | |a Pósa Anikó |e aut |
| 700 | 0 | 1 | |a Varga Csaba |e aut |
| 700 | 0 | 1 | |a Kupai Krisztina |e aut |
| 856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/58187/1/biologica_062_numb_002_180-189.pdf |z Dokumentum-elérés |