Fluorinated beta-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells
Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene-transfec...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | ANTICANCER RESEARCH
35 No. 11 |
| mtmt: | 2962208 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10439 |
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| 100 | 1 | |a Spengler Gabriella | |
| 245 | 1 | 0 | |a Fluorinated beta-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells |h [elektronikus dokumentum] / |c Spengler Gabriella |
| 260 | |c 2015 | ||
| 300 | |a 5915-5919 | ||
| 490 | 0 | |a ANTICANCER RESEARCH |v 35 No. 11 | |
| 520 | 3 | |a Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene-transfected L5178Y mouse T-lymphoma cells. Among them, three P-ylides, Ph3P=C(COCF3)COPh, Ph3P=C(COC2F5)COPh and Ph3P=C(COC3F7)COPh were identified as selectively modulating the ABCB1 pump. These compounds, with low cytotoxicity against mouse T-lymphoma cells, exhibited more potency than the positive control ABCB1 inhibitor verapamil. | |
| 700 | 0 | 1 | |a Ocsovszki Imre |e aut |
| 700 | 0 | 2 | |a Szabó Tönki Ádám |e aut |
| 700 | 0 | 2 | |a Saijo Ryosuke |e aut |
| 700 | 0 | 2 | |a Watanabe Genki |e aut |
| 700 | 0 | 2 | |a Kawase Masami |e aut |
| 700 | 0 | 2 | |a Molnár József |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10439/1/AR_35_beta_diketo_5915_5920_u.pdf |z Dokumentum-elérés |