Activation of TRPV3 regulates inflammatory actions of human epidermal keratinocytes
Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on non-neuronal cell types. Emerging findings have highlighted...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2018
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| Sorozat: | JOURNAL OF INVESTIGATIVE DERMATOLOGY
138 No. 2 |
| doi: | 10.1016/j.jid.2017.07.852 |
| mtmt: | 3319610 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12990 |
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| 100 | 1 | |a Szöllősi Attila Gábor | |
| 245 | 1 | 0 | |a Activation of TRPV3 regulates inflammatory actions of human epidermal keratinocytes |h [elektronikus dokumentum] / |c Szöllősi Attila Gábor |
| 260 | |c 2018 | ||
| 300 | |a 365-374 | ||
| 490 | 0 | |a JOURNAL OF INVESTIGATIVE DERMATOLOGY |v 138 No. 2 | |
| 520 | 3 | |a Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on non-neuronal cell types. Emerging findings have highlighted the role of TRP channels in the skin, where they have been shown to be important in numerous cutaneous functions. Of particular interest is TRPV3, which was first described on keratinocytes. Its functional importance was supported when its gain-of-function mutation was linked to Olmsted syndrome, which is characterized by palmoplantar keratoderma, periorifacial hyperkeratosis, diffuse hypotrichosis and alopecia, as well as itch. In spite of these exciting results, we have no information about the role and functionality of TRPV3 on keratinocytes at the cellular level. In our current study, we have identified TRPV3 expression both on human skin and cultured epidermal keratinocytes. TRPV3 stimulation was found to function as a Ca2+-permeable ion channel which suppresses proliferation of epidermal keratinocytes and induces cell death. Stimulation of the channel also triggers a strong proinflammatory response via the NF-?B pathway. Collectively our data shows that TRPV3 is functionally expressed on human epidermal keratinocytes and that it plays a role in cutaneous inflammatory processes. | |
| 700 | 0 | 1 | |a Vasas Nikolett |e aut |
| 700 | 0 | 1 | |a Angyal Ágnes |e aut |
| 700 | 0 | 1 | |a Kistamás Kornél |e aut |
| 700 | 0 | 1 | |a Nánási Péter Pál |e aut |
| 700 | 0 | 1 | |a Mihály Johanna |e aut |
| 700 | 0 | 1 | |a Béke Gabriella |e aut |
| 700 | 0 | 2 | |a Herczeg-Lisztes Erika |e aut |
| 700 | 0 | 2 | |a Szegedi Andrea |e aut |
| 700 | 0 | 2 | |a Kawada Naoki |e aut |
| 700 | 0 | 2 | |a Yanagida Takashi |e aut |
| 700 | 0 | 2 | |a Mori Takahiro |e aut |
| 700 | 0 | 2 | |a Kemény Lajos |e aut |
| 700 | 0 | 2 | |a Bíró Tamás |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/12990/1/3319610_Szollosi_JID_final_draft_1_u.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/12990/2/Journal_of_investigative_dermatology_2018_2_tartj.pdf |z Dokumentum-elérés |