T-cell subsets in rheumatoid arthritis patients on long-term anti-TNF or IL-6 receptor blocker therapy
Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited. Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry. We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-T...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2017
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| Sorozat: | MEDIATORS OF INFLAMMATION
2017 |
| doi: | 10.1155/2017/6894374 |
| mtmt: | 3288491 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13064 |
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| 024 | 7 | |a 3288491 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
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| 100 | 1 | |a Dulic Sonja | |
| 245 | 1 | 0 | |a T-cell subsets in rheumatoid arthritis patients on long-term anti-TNF or IL-6 receptor blocker therapy |h [elektronikus dokumentum] / |c Dulic Sonja |
| 260 | |c 2017 | ||
| 300 | |a Azonosító: 6894374-Terjedelem: 19 p. | ||
| 490 | 0 | |a MEDIATORS OF INFLAMMATION |v 2017 | |
| 520 | 3 | |a Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited. Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry. We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-TNF nonresponders, and 43 IL-6R antagonist responders, before, 8 weeks and at least 6 months after biological therapy. Untreated RA patients and healthy controls were also included. The important findings are the following: ( 1) the proportion of regulatory T-cells (Tregs) which are decreased in untreated RA patients becomes normal in all long-term-treated groups; ( 2) in anti-TNF responders as well as in nonresponders, the frequencies of naive CD4+ and CD8+ cells are lower, whereas those of proinflammatory Th1, Th2, and Th17 cells and HLA-DR+-activated cells are higher than those in untreated RA or healthy controls; ( 3) in IL-6R responders, Th1 proportion is decreased, while that of Th2 and Th17 is increased as compared to that in anti-TNF-treated patients and controls; ( 4) pending confirmation, a CD4CD69 ratio <2.43 at baseline, could be useful to predict a good therapeutic response to anti-TNF therapy. This study provides comprehensive information regarding the long-term impacts of those biological therapies on the ecotaxis of T-cells in RA. | |
| 700 | 0 | 1 | |a Vásárhelyi Zsófia |e aut |
| 700 | 0 | 1 | |a Sava Florentina |e aut |
| 700 | 0 | 1 | |a Berta László Gergely |e aut |
| 700 | 0 | 1 | |a Szalay Balázs |e aut |
| 700 | 0 | 1 | |a Toldi Gergely |e aut |
| 700 | 0 | 1 | |a Kovács László |e aut |
| 700 | 0 | 1 | |a Balog Attila |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/13064/1/mediators_of_inflammation_u.pdf |z Dokumentum-elérés |