No evidence for the benefit of PPIs in the treatment of acute pancreatitis a systematic review and meta-analysis /
Although current guidelines do not recommend the use of proton pump inhibitors (PPIs) in the standard of care of acute pancreatitis (AP), they are often prescribed in clinical practice, mainly for ulcer stress prophylaxis. In this systematic review and meta-analysis we evaluated the association betw...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | SCIENTIFIC REPORTS
13 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1038/s41598-023-29939-5 |
| mtmt: | 33645754 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/26997 |
| LEADER | 02401nab a2200301 i 4500 | ||
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| 024 | 7 | |a 10.1038/s41598-023-29939-5 |2 doi | |
| 024 | 7 | |a 33645754 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Horváth István László | |
| 245 | 1 | 0 | |a No evidence for the benefit of PPIs in the treatment of acute pancreatitis |h [elektronikus dokumentum] : |b a systematic review and meta-analysis / |c Horváth István László |
| 260 | |c 2023 | ||
| 300 | |a 10 | ||
| 490 | 0 | |a SCIENTIFIC REPORTS |v 13 No. 1 | |
| 520 | 3 | |a Although current guidelines do not recommend the use of proton pump inhibitors (PPIs) in the standard of care of acute pancreatitis (AP), they are often prescribed in clinical practice, mainly for ulcer stress prophylaxis. In this systematic review and meta-analysis we evaluated the association between the use of PPIs in the management of AP and various clinical outcomes. We conducted the systematic research in six databases without restrictions on January 24th, 2022. We investigated adult patient with AP, who were treated with PPI compared to conventional therapy. The pooled odds ratios, mean differences, and corresponding 95% confidence intervals were calculated with random effect model. We included six RCTs and three cohort studies, consisting of 28,834 patients. We found a significant decrease in the rate of pancreatic pseudocyst formation in patients who received PPI treatment. PPI use was associated with a higher risk of GI bleeding, however this finding could be due to the patients' comorbid conditions. We found no significant difference in the rates of 7-day mortality, length of hospital stay, and acute respiratory distress syndrome between the groups. The available data on this topic are limited; therefore, further well designed RCTs are needed to evaluate the potential benefits and adverse effects of PPIs in AP. | |
| 650 | 4 | |a Farmakológia és gyógyszerészet | |
| 700 | 0 | 1 | |a Bunduc Stefania |e aut |
| 700 | 0 | 1 | |a Hankó Balázs |e aut |
| 700 | 0 | 1 | |a Kleiner Dénes |e aut |
| 700 | 0 | 1 | |a Demcsák Alexandra |e aut |
| 700 | 0 | 1 | |a Szabó Bence |e aut |
| 700 | 0 | 1 | |a Hegyi Péter |e aut |
| 700 | 0 | 1 | |a Csupor Dezső |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/26997/1/ScientReport2023HorvathLI.pdf |z Dokumentum-elérés |