Synthesis of Iron(II)-complexes with glyoximes and boric acid derivatives, and their physical-chemical and biological studies
Iron(II) complexes obtained with glyoximes are macrobicyclic ligand systems, which are formed under mild conditions with high yields [1]. The biological activity of these compounds is of particular importance. Some boric acid derivatives have been proposed as new radiopharmaceuticals for boron neutr...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2024
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
30 |
| Kulcsszavak: | Szerves kémia, Anyagkémia, Vas - fizikai-kémiai tulajdonságok |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/85653 |
| Tartalmi kivonat: | Iron(II) complexes obtained with glyoximes are macrobicyclic ligand systems, which are formed under mild conditions with high yields [1]. The biological activity of these compounds is of particular importance. Some boric acid derivatives have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -dioximes, amines, boric acid derivatives, such as [Fe(Ph-Me-DioxH)2L2], [Fe(Me-i-Pr-DioxH)2L2] [Fe(Ph-Me-Diox)3(BO–R)2], [Fe(Bu-Me-Diox)3(BO–R)2], [Fe(i-Pr-Me-Diox)3(BO–R)2], where DioxH, Diox = mono- or bi-deprotonated dioxime, L = 1-naphthylamine, 2-methylimidazole, 2-amino-4-methyl-pyridine, lepidine, m-toluidine, dicyclohexylamine, 2-amino-5- picoline, R = H, methyl, ethyl, isopropyl, n-propyl, isobutyl, n-butyl. For preparation ironII sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines or the other complexing agents were added. The mixture so obtained was refluxed under an inert atmosphere. The molecular structures of our products were studied using a range of techniques, including IR, Raman, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). In addition, their biological activity, including the antimicrobial effect against certain bacterial strains, was also investigated. |
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| Terjedelem/Fizikai jellemzők: | 32-36 |
| ISBN: | 978-963-688-009-5 |