Determination of toxicologically significant impurities in the technical substance prothioconazole
In order to fulfill its potential, a plant protection product must be of satisfactory quality, which, among other things, implies that the active substance has the appropriate characteristics. In the synthesis of the active substance, a technical product is created. Besides the active substance, it...
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| Dokumentumtípus: | Könyv része |
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University of Szeged
Szeged
2025
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
31 |
| Kulcsszavak: | Analitikai kémia, Toxikológia, Környezetkémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/88620 |
| Tartalmi kivonat: | In order to fulfill its potential, a plant protection product must be of satisfactory quality, which, among other things, implies that the active substance has the appropriate characteristics. In the synthesis of the active substance, a technical product is created. Besides the active substance, it could contain various impurities formed during the production process. The quality of technical substance is of great importance since it can contain contaminants that can harm human and animal health. Therefore, it is necessary, before using the technical substance, to determine the content of impurities of toxicological significance. The determination is carried out using appropriate qualitative and quantitative analytical methods. This study aimed to determine prothioconazole-desthio and toluene, impurities of toxicological significance in the technical material of the fungicide prothioconazole, widely applied to protect field crops from various phytopathogenic fungi. To determine the prothioconazole-desthio impurity in the prothioconazole technical substance, the high-performance liquid chromatography (HPLC) method was validated, while the gas chromatography (GC) method was assessed for the determination of toluene. Validation parameters such as linearity of the detector response, precision and accuracy of the method, limit of detection and limit of quantification were tested. The obtained results showed that all tested parameters fully met the requirements, thus confirming the methods’ reliability for the determination of impurities prothioconazole-desthio and toluene in technical substance prothioconazole. |
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| Terjedelem/Fizikai jellemzők: | 56-60 |
| ISBN: | 978-963-688-078-1 |