Synthesis of pyrrolo[1,2-a]pyrimidine enantiomers via domino ring-closure followed by retro diels-alder protocol
From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols, where the chirality of the desired products i...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2017
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| Sorozat: | MOLECULES
22 No. 4 |
| doi: | 10.3390/molecules22040613 |
| mtmt: | 3266854 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12517 |
| Tartalmi kivonat: | From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols, where the chirality of the desired products is transferred from norbornene derivatives. The stereochemistry of the synthesized compounds was proven by X-ray crystallography. The absolute configuration of the product is determined by the configuration of the starting amino hydroxamic acid. |
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| Terjedelem/Fizikai jellemzők: | Azonosító: 613-Terjedelem: 13 p. |
| ISSN: | 1420-3049 |