Synthesis of Analogues of Thyrotropin-Releasing Hormone
The synthesis of ten new thyrotropin-releasing hormone analogues (15-24) which contain uncoded amino acids (L- and D-homoleucine, L- and D-homophenylalanine, L-homoproline and 6-ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl e...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1994
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| Sorozat: | JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG
336 No. 6 |
| Tárgyszavak: | |
| doi: | 10.1002/prac.19943360609 |
| mtmt: | 1880328 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31990 |
| Tartalmi kivonat: | The synthesis of ten new thyrotropin-releasing hormone analogues (15-24) which contain uncoded amino acids (L- and D-homoleucine, L- and D-homophenylalanine, L-homoproline and 6-ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N-protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive. |
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| Terjedelem/Fizikai jellemzők: | 525-529 |
| ISSN: | 0941-1216 |