In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers
Some of the phenothiazines and dibenz[b,flazepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leuk...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | ANTICANCER RESEARCH
12 No. 1 |
| Tárgyszavak: | |
| mtmt: | 1791859 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32259 |
| Tartalmi kivonat: | Some of the phenothiazines and dibenz[b,flazepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leukocytes. The superoxide dismutase inhibition by 7,8-dioxochlorpromazine and 6,9-dioxochlorpromazine have some relation to the growth inhibitory action on the growth of HEP-2 and prolactinoma cells in vitro. The antiproliferative effects of phenothiazines were synergized with resistance modifers like verapamil, omeprazole and tubulozole-C, due to increased drug-influx or decreased drug-efflux and due to possible action on the cytoskeleton. |
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| Terjedelem/Fizikai jellemzők: | 273-280 |
| ISSN: | 0250-7005 |