Antiplasmid activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines
Various synthetic derivatives of phenothiazines, benzo[a]phenothiazines and benz[c]acridines were compared for their abilities to induce antiplasmid activity against E. coli F'lac plasmid. Several phenothiazine derivatives were much more potent in antiplasmid activity than benzo[a]phenothiazine...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | ANTICANCER RESEARCH
12 No. 1 |
| Tárgyszavak: | |
| mtmt: | 1903099 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32263 |
| Tartalmi kivonat: | Various synthetic derivatives of phenothiazines, benzo[a]phenothiazines and benz[c]acridines were compared for their abilities to induce antiplasmid activity against E. coli F'lac plasmid. Several phenothiazine derivatives were much more potent in antiplasmid activity than benzo[a]phenothiazine- or benz[c]acridine derivatives. Their antiplasmid activity seemed to be enhanced by Cl- or CF3- substitution at 2 C atom, and modified by the side chain length and charge at the L-region of the molecules, as well as by hydrophilicity. |
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| Terjedelem/Fizikai jellemzők: | 135-139 |
| ISSN: | 0250-7005 |