Synthesis of Segments of the GnRH‐Associated Peptide
The 56 amino acid containing GnRH-associated peptide (GAP) may be prepared by a combination of fragment condensation and solid-phase peptide synthesis (SPPS). The solution-phase synthesis of the fragments 1 - 9 is described. Furthermore, we report on the selective cleavage of benzyl esters by cataly...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | LIEBIGS ANNALEN DER CHEMIE
1992 No. 10 |
| Tárgyszavak: | |
| doi: | 10.1002/jlac.1992199201174 |
| mtmt: | 1880331 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32284 |
| Tartalmi kivonat: | The 56 amino acid containing GnRH-associated peptide (GAP) may be prepared by a combination of fragment condensation and solid-phase peptide synthesis (SPPS). The solution-phase synthesis of the fragments 1 - 9 is described. Furthermore, we report on the selective cleavage of benzyl esters by catalytic hydrogenation in the presence of the 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group. The C-terminal 15 amino acid containing fragment of GAP (10) was synthesized by SPPS. |
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| Terjedelem/Fizikai jellemzők: | 1055-1061 |
| ISSN: | 0170-2041 |