Unveiling the Anticancer Potential of Verbascum aydogdui Isolation, Characterization, and In Vitro Studies /
Cytotoxic activity‐guided fractionation of the ethanolic extract of Verbascum aydogdui , an endemic halophyte plant to Türkiye, resulted in the isolation of 16 secondary metabolites, including eight triterpene saponins, mulleinsaponins III ( 1 ), ilwensisaponin A ( 2 ), buddlejasaponin I ( 3 ), mull...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | CHEMISTRY & BIODIVERSITY
23 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1002/cbdv.202503376 |
| mtmt: | 36857071 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/38745 |
| Tartalmi kivonat: | Cytotoxic activity‐guided fractionation of the ethanolic extract of Verbascum aydogdui , an endemic halophyte plant to Türkiye, resulted in the isolation of 16 secondary metabolites, including eight triterpene saponins, mulleinsaponins III ( 1 ), ilwensisaponin A ( 2 ), buddlejasaponin I ( 3 ), mulleinsaponin IV ( 4 ), ilwensisaponins D ( 5 ), ilwensisaponin C ( 6 ), craniosaponin A ( 7 ) and buddlejasaponin Ia ( 8 ), six iridoid glycosides, aucubine ( 9 ), eurostoside ( 10 ), geniposidic acid ( 11 ), nigroside III ( 13 ), 6‐ O ‐β‐D‐glucopyranosylaucubine ( 12 ), 6‐ O ‐[3‐ O ‐( E ‐feruloyl)‐α‐L‐rhamnopyranosyl]‐aucubine ( 14 ), and two phenylethanoid glycosides, verbascoside ( 15 ) and alyssonoside ( 16 ). Compounds 1 – 5 displayed significant cytotoxicity against PC3, HEPG2, HGC27, A375, MCF7, and SW480 cancer cell lines with half‐maximal inhibitory concentration values of 17.6–85.1 µM, being 2 and 3 the most cytotoxic ones. Thus, 2 and 3 were further assayed for their cell death mechanisms, including apoptosis and necrosis. Compound 2 exerted anti‐cancer effects in all cancer cell lines tested, except for MCF7, especially via inducing apoptosis. Its apoptotic activity was predominantly mediated by a significant increase in p53 and p21 expressions in all cancer lines tested, but for SW480. This is the first bioactivity and phytochemical study on V. aydogdui . Our results indicated that 2 could be a potential anticancer natural product that merits further in vitro and in vivo studies. |
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| Terjedelem/Fizikai jellemzők: | 9 |
| ISSN: | 1612-1872 |